Though at first glance this seems like a pretty straightforward question, beware! Here the interviewer is looking to see if you've any regrets and if you really do want the job. You'll be amazed at the amount of people who respond with "well I wouldn't have done engineering (or whatever occupation they're in); there are just not many job prospects"! And what's this saying about you - you don't have much belief in yourself or your ability to get a job! Interview over!! Below are some examples of bad responses and of course some good ones!
Bad/inappropriate responses:
"If I could start my career over - I probably would have worked harder at school and then studied medicine". Sounds harmless enough but you're really letting the interviewer know that you're not in your ideal career field and you're where you are now because you failed to apply yourself in school i.e. you're not committed to your career!!
"I would have done something that would allow me to make a difference in the world, like help fight poverty/disease etc. Hey you're not in a Miss World or Mr Universe competition! While you may be passionate about world poverty etc try and keep focused on the job at hand i.e. the interview. Sure you can mention your passion and the fact that you volunteer with the Salvos but not when responding to this question.
Good/appropriate responses:
Regrets, yes we've all had a few but it's on a need to know basis and the interview is not the time to air your regrets! Try the following:
"That's an interesting question, but when I look back on my career and reflect on the choices I've made, there's nothing really I'd change. Every job I've had has been a learning experience and has added value to my skill set. In fact this is what makes this job so attractive as it allows me to use those skills I have gathered to date and make a meaningful contribution etc etc" (find something that attracts you to this role or organisation and make sure you mention it here).
If you're pushed to come up with something as the interviewer says "surely there must have been some jobs you regretted having", stick to your guns and respond "everyone has had a job that didn't turn out as expected, but really this provides an opportunity to learn and grow, and honestly nothing springs to mind that's relevant here". By sticking to your guns you'll find the interviewer will back down as they know you've not fallen for the bait.
To be convincing though you'll have to practice your response to this one and genuinely believe in what you're saying.